| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C20H30O4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Agathic acid is an orally active diterpenoid resin acid that can be isolated from coniferous plants such as Agathis and Araucaria. It exhibits anti-inflammatory, antibacterial, antioxidant, and antitumor activities and can be used in research on bacterial infections, inflammation, and cancer[1][2][3]. It has the molecular formula C20H30O4 (MW 334.45).
Physical & Chemical Properties
| CAS Number | 640-28-8 |
|---|---|
| Molecular Formula | C20H30O4 |
| Molecular Weight | 334.45 g/mol |
| SMILES | O=C([C@@]1(C)CCC[C@]2(C)[C@@H](CC/C(C)=C/C(O)=O)C(CC[C@@]12[H])=C)O |
| Target | Leishmania |
| Signaling Pathway | Metabolic Enzyme/Protease; Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
Leishmania 28.0 μg/mL (IC50, Promastigote) |
Leishmania 17.0 μg/mL (IC50, Amastigote) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Within the tested dose range, Agathic acid shows no activity against A2780 cells[1]. Agathic acid (72 h) inhibits proliferation of Leishmania amazonensis promastigotes and amastigotes, giving IC50 values of 28.0 μg/mL and 17.0 μg/mL, respectively[2]. In in vitro-cultured Leishmania amazonensis amastigotes, Agathic acid (100 μg/mL; 3 h) significantly raises plasma membrane permeability, with 63.4% of cells positive for Propidium Iodide uptake. It also induces mitochondrial membrane potential depolarization, lowering the proportion of cells with Rhodamine 123 fluorescence to 27.5%[2]. In human erythrocytes, Agathic acid (3 h) shows a CC50 of 350 μg/mL, with a selectivity index of 20.6 against Leishmania amazonensis amastigotes[2].
Cell Viability Assay[2]
| Cell Line | Leishmania amazonensis |
|---|---|
| Concentration | 100 μg/mL |
| Incubation Time | 3 h |
| Result | Potently inhibited the activity of the parasites and 63.4% of the cells tested positive for Propidium Iodide uptake. |
In Vivo
In a healthy, late-gestation mixed-breed beef cattle model, Agathic acid (102-144 mg/kg; oral administration; twice daily until abortion) causes preterm labor and abortion[3].
| Animal Model | Mixed-breed beef cows (healthy, experimentally naïve, 465-650 kg, late-term pregnant)[3] |
|---|---|
| Dosage | 102 mg/kg; 134 mg/kg; 144 mg/kg |
| Administration | p.o.; twice daily; until abortion |
| Result | Induced abortion in treated cows after 6, 5, and 4 days of treatment, respectively. Showed a dose-response relationship where higher daily doses correlated with fewer days to abortion. Detected agathic acid, dihydroagathic acid, and tetrahydroagathic acid in serum samples, with higher serum concentrations of agathic and dihydroagathic acid in cows that aborted earlier. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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