| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C28H23NaO2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
AGN 193109 sodium is the sodium salt form of AGN 193109 and acts as a pan antagonist of the retinoic acid receptor (RAR), with Kd values of 2, 2, and 3 nM for RARα, RARβ, and RARγ, respectively. It reverses TTNPB-induced morphological changes and the proliferation suppression induced by all-trans retinoic acid (tRA), 9-cis RA, and 13-cis RA in ECE16-1 cells, and acts as an antidote for retinoic acidosis by ameliorating skin and mucosal toxicity[1][2]. Its molecular formula is C28H23NaO2, with a molecular weight of 414.47 g/mol.
Physical & Chemical Properties
| CAS Number | 2319838-82-7 |
|---|---|
| Molecular Formula | C28H23NaO2 |
| Molecular Weight | 414.47 g/mol |
| SMILES | O=C(O[Na])C1=CC=C(C#CC2=CC=C3C(C)(C)CC=C(C4=CC=C(C)C=C4)C3=C2)C=C1 |
| Target | RXR α, RXR β, RXR γ |
| Signaling Pathway | Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
|
RXR α 2 nM (Kd) |
RXR β 2 nM (Kd) |
RXR γ 2 nM (Kd) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells. Cancer Res 2023 Jul 14;83(14):2387-2404. PMID: 37184371
All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer. Nat Commun 2026 May 11. PMID: 42115161
Targeting ALDH1A1 to enhance the efficacy of KRAS-targeted therapy through ferroptosis. Redox Biol 2024 Nov:77:103361. PMID: 39317105
Acta Pharm Sin B. 2026 Jul 8.
CAR-M2 immunotherapy resolves renal fibrosis via revascularization and apoptosis of profibrotic Cxcr2+ endothelial cells. Cell Rep Med 2026 Apr 21;7(4):102698. PMID: 41887221
Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing. Sci Adv 2020 Nov 4;6(45):eaaz1410. PMID: 33148658
Retinoic acid enhances γδ T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion. Cell Commun Signal 2025 Mar 29;23(1):156. PMID: 40158172
The bile acid-activated retinoic acid response in dendritic cells is involved in food allergen sensitization. Allergy 2022 Feb;77(2):483-498. PMID: 34365653
Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes. Front Pharmacol 2025 Apr 24:16:1562244. PMID: 40343007
All-trans retinoic acid-mediated ADAR1 degradation synergizes with PD-1 blockade to suppress pancreatic cancer. bioRxiv 2024 Oct 23:2024.10.20.619300. PMID: 39484589
