| Field | Specification |
|---|---|
| Mfr No | |
| Accession Number | |
| Alternative Names | AHSA1, AHA1, HSPC322, p38, C14orf3, LOC10598, Activator of Hsp90 ATPase activity 1, Activator of 90 kDa heat shock protein ATPase homolog 1 |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | Recombinant Full Length Mouse Aha1 Protein |
| Product Type | |
| Reactivity | |
| Shipping | |
| Storage | |
| Target |
Activator of HSP90 ATPase Homolog 1 (AHA1) is a critical member of the HSP90 co-chaperone family, known for its role in regulating protein folding and stability. AHA1 enhances the ATPase activity of HSP90, a central molecular chaperone, by competitively displacing other co-chaperones such as p23, thereby accelerating the chaperone cycle and influencing client protein maturation.
AHA1 is implicated in endoplasmic reticulum (ER) to Golgi trafficking, a process essential for proper protein sorting and cellular homeostasis. It also interacts with HSP90 (HSPCA) and the cytoplasmic tail of vesicular stomatitis virus glycoproteins (VSV G), suggesting a broader role in viral pathogenesis and intracellular transport mechanisms.
Importantly, AHA1 is widely expressed across multiple tissues, including the brain, heart, skeletal muscle, and kidney, with lower expression levels observed in the liver and placenta. Its presence in the central nervous system highlights its potential relevance in neurodegenerative disease pathways, where protein misfolding and aggregation are hallmark features.
Emerging evidence suggests that targeting AHA1 may enhance the efficacy of HSP90 inhibitors, positioning it as a promising therapeutic co-target in diseases characterized by proteostasis imbalance, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.
1 µl/ml of SPC-183 was sufficient for detection of Aha1 in 10 µg of mixed human cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SPC-183D — Size: 100 uL: AHA1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-183D, RRID: AB_2224092)
- SPC-183D-A390 — Size: 100 uL: AHA1 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-183D-A390, RRID: AB_2703959)
- SPC-183D-A488 — Size: 100 uL: AHA1 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-183D-A488, RRID: AB_2703960)
- SPC-183D-A594 — Size: 100 uL: AHA1 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-183D-A594, RRID: AB_2703962)
- SPC-183D-APC — Size: 100 uL: AHA1 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-183D-APC, RRID: AB_2703968)
- SPC-183D-BI — Size: 100 uL: AHA1 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-183D-BI, RRID: AB_2703969)
- SPC-183D-FITC — Size: 100 uL: AHA1 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-183D-FITC, RRID: AB_2703970)
- SPC-183D-HRP — Size: 100 uL: AHA1 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-183D-HRP, RRID: AB_2703971)
- SPC-183D-PCP — Size: 100 uL: AHA1 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-183D-PCP, RRID: AB_2703973)
- SPC-183D-RPE — Size: 100 uL: AHA1 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-183D-RPE, RRID: AB_2703974)
- SPC-183S — Size: 12 uL: AHA1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-183S, RRID: AB_2224092)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796.
3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723.
4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.
