| Field | Specification |
|---|---|
| Target | |
| Applications | |
| Molecular weight | |
| Molecular formula | C19H14ClN5O2S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
AKT-IN-18 is an inhibitor of Akt, with an IC50 of 69.45 μM in A549 cells. It induces apoptosis and can be used in non-small cell lung cancer studies[1]. It has a molecular formula of C19H14ClN5O2S and a molecular weight of 411.86 g/mol.
Physical & Chemical Properties
| Molecular Formula | C19H14ClN5O2S |
|---|---|
| Molecular Weight | 411.86 g/mol |
| SMILES | O=C(N/N=C/C1=CC=C(N2C=CN=C2)C=C1)CSC3=NC4=CC(Cl)=CC=C4O3 |
| Target | Akt |
| Signaling Pathway | PI3K/Akt/mTOR; Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
Akt 69.45 μM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
AKT-IN-18 (0-500 μM; 24 hours) is cytotoxic to A549 cells and induces apoptosis[1].
Apoptosis Analysis[1]
| Cell Line | A549, L929 cells |
|---|---|
| Concentration | 0-500 μM |
| Incubation Time | 24 hours |
| Result | Exerted cytotoxic activity against A549 cells with IC50 of 83.59 μΜ without influencing normal (L929) cells at effective doses. Induced early apoptosis caused at 2.7% and late apoptotic cells at 6.04%. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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