| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Natural |
| Storage | |
| Target |
Product details
- Chemical name: 1,2,4-trimethoxy-5-[(E)-prop-1-enyl]benzene.
- Also known as: Asarone, trans-Isoasarone, Etherophenol
- CAS number: 2883-98-9
- Molecular formula: C12H16O3.
- Purity: >99%
- Concentration: 1-500 µM.
- Form: Lyophilized powder.
- Solubility: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: NaV channels, GABA(A) receptors, TrkB receptors, NMDA receptors
- Source: Natural
- Activity: α-Asarone 100 μM to 1 mM inhibits NaV1.2 channel currents. It also blocks GABA(A) receptors in neurons1. α-Asarone blocks corticosterone-induced anxiety-like behaviours via modulating TrkB signaling process2.
- Alternative names: Asarone, trans-Isoasarone, Etherophenol
Scientific background
α-Asarone is an active component of the Chinese medicinal plant Acorus tatarinouii Schott and exhibits a variety of pharmacological activities such as anti-hyperlipidemic, anti-coagulant, anti-tumor, anti-viral, and anti-inflammatory1,2.α-Asarone acts as a NaV channel blocker, GABA(A) receptor blocker and TrkB receptor inhibitor and is available in the market in the form of tablets, capsules and injections1.The neuroprotective actions of α-asarone are exhibited through the blockade of N-methyl-D-aspartate (NMDA) receptor and by inhibition of nitric oxide (NO) overproduction in brain tissue. α-Asarone also exhibits anti-oxidative properties, reduces levels of superoxide dismutase (SOD), catalase, and glutathione peroxidase in the hippocampus against noise-stress and in various seizure models3.Recent studies have shown that α-asarone has the ability to improve multiple physiological actions, to produce a variety of pharmacological actions in the CNS and modulate immune system functions. The anti-convulsant activity of α-asarone has been reported in several recent studies in epileptic seizure animal models3.α-Asarone was shown to be effective in attenuating foam cell formation and enhancing cholesterol efflux4. In addition, it protects against angiotensin II-mediated damage of endothelial cells and can be developed for the prevention of injury to cardiovascular tissues2.α-Asarone may serve as a preventive and regenerative therapeutic agent to promote neurogenesis against age-related neurodegeneration and neurodegenerative disorders5.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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