| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid; CD336; NSC 608001; Ro 40-6055 |
| Cas No. | |
| Form | Off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (35 mg/ml); or Ethanol (18 mg/ml) |
| Source | Synthetic |
| Storage |
AM 580 is a selective agonist of the retinoic acid receptor alpha (RARα), structurally related to retinoic acid. It modulates immune responses by promoting Th2 cytokine production and suppressing Th1 cytokines. In neurodegenerative disease research, AM 580 has been shown to inhibit microglial activation and reduce neuroinflammation, particularly in Alzheimer’s disease models. Its ability to influence retinoid signaling pathways and immune modulation makes it a promising candidate for therapeutic development in neuroinflammatory and neurodegenerative conditions.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
AM 580 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-600)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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