| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Natural |
| Storage | |
| Target |
Product details
- Chemical name: 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one.
- Also known as: 3',8''-Biapigenin, Didemethyl-ginkgetin
- CAS number: 1617-53-4
- Molecular formula: C30H18O10.
- Purity: ≥98.5%
- Concentration: 0.5 nM - 0.5 µM.
- Form: Lyophilized powder.
- Solubility: 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: GABA(A) receptors
- Source: Natural
- Activity: Amentoflavone is a negative allosteric modulator of GABA(A) receptor inhibitory activity, with EC50=4 µM on recombinant α1β2γ2L GABA(A) in oocytes1. In vitro, it potently displaces benzodiazepine binding to rat brain membranes with nM affinity2, and inhibits binding at other GPCRs3.
- Alternative names: 3',8''-Biapigenin, Didemethyl-ginkgetin
Scientific background
Amentoflavone is a natural compound derived from the plant Selaginella tamariscina. It is a negative allosteric modulator of GABA(A) receptors. Amentoflavone can be found in a number of plants with medicinal properties including Ginkgo biloba and Hypercium perforatum. Amentoflavone is the first high affinity ligand known for the benzodiazepine receptor devoid of nitrogen in its structure. It has been hypothesized recently that amentoflavone can cross the blood brain barrier in vivo by passive diffusion. In addition to its effect on GABA receptors, amentoflavone inhibits binding at 5-HT, D3-dopamine and δ-opioid receptors. The action of amentoflavone on the GABA(A) receptor is independent of high affinity benzodiazepine modulatory sites on the receptor. Amentoflavone and other substances of the flavone class have been found to exert anxiolytic activity in mice without the side effect associated with the use of benzodiazepines1.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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