| Field | Specification |
|---|---|
| Target | |
| Alternative names | AHGDM hydrochloride |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C34H53ClN4O8 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Aminohexylgeldanamycin hydrochloride, also known as AHGDM hydrochloride, is a derivative of Geldanamycin and a potent inhibitor of HSP90. It shows antiangiogenic and antitumor activities[1]. It has the molecular formula C34H53ClN4O8 and a molecular weight of 681.26 g/mol.
Physical & Chemical Properties
| CAS Number | 1146534-45-3 |
|---|---|
| Molecular Formula | C34H53ClN4O8 |
| Molecular Weight | 681.26 g/mol |
| SMILES | [H]Cl.O=C(C(NCCCCCCN)=C1C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(C)\C2=O)C=C(N2)C1=O |
| Target | HSP90 |
| Signaling Pathway | Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Antibody-Drug Conjugate/ADC Related |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Cell surface-expressed GRP78 in prostate cancer is targeted by HPMA copolymer-aminohexylgeldanamycin conjugates[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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