| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Source | Plant — Leguminosae Amorpha fruticosaL. |
| Molecular weight | |
| Molecular formula | C23H22O7 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Amorphigenin is a trothotenone compound that inhibits osteoclast differentiation by suppressing expression of c-Fos and NFATc1 in activated T cells. It degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, independent of the mTOR pathway, and significantly protects bone mass while reducing bone erosion in a mouse model of inflammatory bone loss. It can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders[1][2]. It has a molecular formula of C23H22O7 and a molecular weight of 410.42 g/mol.
Physical & Chemical Properties
| CAS Number | 4208-09-7 |
|---|---|
| Molecular Formula | C23H22O7 |
| Molecular Weight | 410.42 g/mol |
| Structure Classification | Flavonoids Other Flavonoids |
| SMILES | O=C1[C@@]2([C@]([H])(OC3=C1C=CC4=C3C[C@@H](O4)C(CO)=C)COC5=C2C=C(C(OC)=C5)OC)[H] |
| Target | c-Fos |
| Signaling Pathway | Immunology/Inflammation; PI3K/Akt/mTOR; Epigenetics; Autophagy |
| Initial Source | Plant — Leguminosae Amorpha fruticosaL. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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