| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(thiophen-2-ylmethyl)benzamide;hydrochloride.
- CAS number: 926023-82-7
- Molecular formula: C23H27ClN2O2S.
- Purity: >97%
- Concentration: 1-100 µM.
- Form: Lyophilized powder.
- Solubility: Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
- Reconstitution: Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: TRPM8 channel
- Source: Synthetic
- Activity: AMTB hydrochloride is a TRPM8 channel blocker, inhibiting icilin-induced human TRPM8 channel activation (pIC50 = 6.23), selective over TRPV1 and TRPV41.
Scientific background
AMTB hydrochloride is a TRPM8 channel blocker, able to inhibit icilin-induced human TRPM8 channel activation. The compound shows very little affinity for TRPV1 and TRPV4 channels and is being used as a tool to evaluate the role of TRPM8 channels in different animal models1. TRPM8 channel blockers may provide a new therapeutic treatment for overactive and painful bladder syndrome1,2.TRPM8 channel is a member of the TRP channel superfamily. TRPM8 is a Ca2+-permeable, nonselective cation channel that is activated by temperatures in the range of 8-28°C and by chemical agonists such as menthol and icilin. The channel is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons. It's expression is up-regulated in prostate cancer and other malignancies3,4.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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