| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Plant — Rosaceae Prunus persica L. |
| Molecular weight | |
| Molecular formula | C20H28O13 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Amygdalinic acid by the manufacturer is a glycoside that can be isolated from Persicae Semen. It inhibits Epstein-Barr virus early antigen activation and delays two-stage chemical carcinogenesis in mouse skin, reducing papilloma incidence[1]. It has the molecular formula C20H28O13 and a molecular weight of 476.43 g/mol.
Physical & Chemical Properties
| CAS Number | 66427-92-7 |
|---|---|
| Molecular Formula | C20H28O13 |
| Molecular Weight | 476.43 g/mol |
| Structure Classification | Ketones, Aldehydes, Acids |
| SMILES | OC([C@@H](C1=CC=CC=C1)O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=O |
| Signaling Pathway | Anti-infection |
| Initial Source | Plant — Rosaceae Prunus persica L. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In Raji cells, Amygdalinic acid (10-1000 mol ratio/TPA; 48 h) inhibits EBV-EA activation in a concentration-dependent manner; the strongest inhibition (3.5 ± 0.3% relative control) occurs at 1000 mol ratio/TPA, with 60% cell viability[1].
Immunofluorescence[1]
| Cell Line | Raji cells (Burkitt's lymphoma-derived lymphoblastoid cells) |
|---|---|
| Concentration | 10-1000 mol ratio/TPA |
| Incubation Time | 48 h |
| Result | Reduced EBV-EA activation to 3.5 ± 0.3% relative to the positive control, with 60% Raji cell viability at 1000 mol ratio/TPA. Reduced EBV-EA activation to 34.1 ± 1.2% relative to the positive control, with >80% Raji cell viability at 500 mol ratio/TPA. Reduced EBV-EA activation to 65.0 ± 1.9% relative to the positive control, with >80% Raji cell viability at 100 mol ratio/TPA. Reduced EBV-EA activation to 95.7 ± 0.4% relative to the positive control, with >80% Raji cell viability at 10 mol ratio/TPA. |
In Vivo
In a two-stage skin carcinogenesis mouse model, Amygdalinic acid (85 nmol; twice weekly) exhibits anti-tumor promoting activity and reduces papilloma incidence to a level similar to that seen with (-)-Epigallocatechin gallate[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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