| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | amyloid beta (A4) protein; ABETA; ABPP; APP; APPI; amyloid beta A4; beta amyloid; Amyloid-Beta; Amyloid Beta; AB |
| Clonality | |
| Concentration | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthesized peptide derived from human Amyloid-β |
| Isotype | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
Primary AntibodyThis antibody targets APP and detects endogenous levels of APP protein.
Validated Applications
| Application | Dilution Guidance |
|---|---|
| Immunohistochemistry (IHC) | Refer to datasheet for recommended working dilution |
| Immunofluorescence (IF) | Refer to datasheet for recommended working dilution |
| Western Blot (WB) | Refer to datasheet for recommended working dilution |
Antibody Specifications
| Target | APP |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Reactivity | Human, Rat, Mouse |
| Purification | Affinity Purification |
| Concentration | 1 mg/ml |
| Immunogen | Synthesized peptide derived from human Amyloid-β |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Gene ID | Human: 351 |
| UniProt | P05067 (Human: P05067) |
Scientific Background
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation| while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition| two of the peptides are antimicrobial peptides| having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Alternative Names
amyloid beta (A4) protein; ABETA; ABPP; APP; APPI; amyloid beta A4; beta amyloid; Amyloid-Beta; Amyloid Beta; AB
Safety & Handling
| Target | APP |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Reactivity | Human, Rat, Mouse |
| Purification | Affinity Purification |
| Concentration | 1 mg/ml |
| Immunogen | Synthesized peptide derived from human Amyloid-β |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Gene ID | Human: 351 |
| UniProt | P05067 (Human: P05067) |
Optimized working dilutions depend on sample type and detection system. Titration is recommended.
| Application | Dilution Note |
|---|---|
| Immunohistochemistry (IHC) | Refer to datasheet for recommended working dilution |
| Immunofluorescence (IF) | Refer to datasheet for recommended working dilution |
| Western Blot (WB) | Refer to datasheet for recommended working dilution |
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation| while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition| two of the peptides are antimicrobial peptides| having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Alternative Names
amyloid beta (A4) protein; ABETA; ABPP; APP; APPI; amyloid beta A4; beta amyloid; Amyloid-Beta; Amyloid Beta; AB
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
