| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Source | Plant — Compositae Simsia foetida (Cav.) S.F.Blake; Plant — Acanthaceae |
| Molecular weight | |
| Molecular formula | C24H26O11 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Andrographidine E inhibits both COX-2 (IC50 = 19 μM) and HDAC, showing high affinity for the HDAC1 and HDAC3 isoforms. It can bind specifically to macrophages, suggesting potential immunotargeting properties, and can be used in inflammation research[1][2][3]. It has the molecular formula C24H26O11 and a molecular weight of 490.46 g/mol.
Physical & Chemical Properties
| CAS Number | 113963-41-0 |
|---|---|
| Molecular Formula | C24H26O11 |
| Molecular Weight | 490.46 g/mol |
| Structure Classification | Flavonoids Flavones |
| SMILES | COC1=C2C(C(C=C(C3=C(C=CC=C3)OC)O2)=O)=C(C=C1OC)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO |
| Target | HDAC1, HDAC3, COX-2 |
| Signaling Pathway | Immunology/Inflammation; Epigenetics; Cell Cycle/DNA Damage |
| Initial Source | Plant — Compositae Simsia foetida (Cav.) S.F.Blake; Plant — Acanthaceae |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
[1][3]
|
COX-2 19 μM (IC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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