| Field | Specification |
|---|---|
| Target | |
| Alternative names | Angiotensin-converting enzyme 2;3.4.17.23;ACE-related carboxypeptidase;Angiotensin-converting enzyme homolog;ACEH;Metalloprotease MPROT15;Processed angiotensin-converting enzyme 2;ACE2;UNQ868/PRO1885; |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human ACE2 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone GEE-1 is a rabbit monoclonal antibody that recognizes angiotensin-converting enzyme 2 (gene ACE2) in human, mouse and rat samples and is validated for Western blot, IHC, ICC/IF and immunoprecipitation. The predicted molecular weight is 92.5 kDa, and the supplier reports an observed band at about 92 kDa.
Angiotensin-converting enzyme 2 (ACE2) is a membrane carboxypeptidase that converts angiotensin II to angiotensin 1-7, counterbalancing ACE in the renin-angiotensin system. It is also the cell-entry receptor for SARS-CoV and SARS-CoV-2 and helps with amino acid transport in the gut.
| Target | Angiotensin-converting enzyme 2 (gene ACE2; UniProt Q9BYF1, human) |
|---|---|
| Clone | GEE-1 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 92.5 kDa |
| Observed MW | 92 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|---|
| Immunohistochemistry | 1:20–1:100 |
| Immunocytochemistry / Immunofluorescence | 1:20–1:100 |
| Immunoprecipitation | 1:20 |
Samples with confirmed staining (IHC): rat liver tissue, rat stomach tissue, human lung large cells cancer tissue, human liver cancer tissue, human squamous cells carcinoma tissue, human kidney tissue.
Recommended antigen retrieval: heat-mediated, in TE buffer (pH 9.0); citrate buffer (pH 6.0) can be used instead.
Immunogen
Synthetic peptide based on the sequence of human ACE2.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places angiotensin-converting enzyme 2 in the SUBCELLULAR LOCATION: Cell membrane, cytoplasm, cell projection and apical cell membrane. Tissue expression noted by UniProt (human): Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells (at protein level). The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Nan Li et al. (2025) An inhalable composite particulate system for targeted delivery of therapeutics deep into small airways: in vitro and in vivo evaluation. International Journal of Pharmaceutics. 10.1016/j.ijpharm.2025.126053
Mao-liang Huang et al. (2009) Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors. Clinical and Experimental Pharmacology and Physiology. 10.1111/j.1440-1681.2009.05302.x
Mahi Balcı et al. (2025) Immunohistochemical Evaluation of SARS-CoV-2 Nucleoprotein and ACE2 Markers in Testicular Tumors Diagnosed During the COVID-19 Pandemic. Clinical Medicine Insights-Oncology. 10.1177/11795549251347339
Wang Wanyu et al. (2018) Telmisartan protects chronic intermittent hypoxic mice via modulating cardiac renin-angiotensin system activity. BMC Cardiovascular Disorders. 10.1186/s12872-018-0875-4
