| Field | Specification |
|---|---|
| Target | |
| Alternative names | Type-1 angiotensin II receptor;AT1AR;AT1BR;Angiotensin II type-1 receptor;AT1;AGTR1;AGTR1A, AGTR1B, AT2R1, AT2R1B; |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human AGTR1 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone AOGD-1 is a rabbit monoclonal antibody that recognizes type-1 angiotensin II receptor (gene AGTR1) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 41.1 kDa, and the supplier reports an observed band at about 38 kDa.
The angiotensin II type 1 receptor (AT1R, AGTR1) is a G protein-coupled receptor that mediates most known actions of angiotensin II. Through Gq and phospholipase C it raises intracellular Ca2+ and drives vasoconstriction, aldosterone release and sodium retention, and it is the target of angiotensin receptor blocker drugs used in hypertension research.
| Target | Type-1 angiotensin II receptor (gene AGTR1; UniProt P30556, human) |
|---|---|
| Clone | AOGD-1 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 41.1 kDa |
| Observed MW | 38 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Samples with a confirmed band (WB): HeLa cells, PC-12 cells.
Recommended loading (WB): 20–40 µg of total protein per lane.
Immunogen
Synthetic peptide based on the sequence of human AGTR1.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places type-1 angiotensin II receptor in the cell membrane. Tissue expression noted by UniProt (human): Liver, lung, adrenal and adrenocortical adenomas. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Fei Qian et al. (2025) Chlorogenic Acid Ameliorates Chronic Unpredictable Stress-Induced Diminished Ovarian Reserve Through Ovarian Renin-Angiotensin System. Molecular Nutrition & Food Research. 10.1002/mnfr.202400814
Shuai B. et al. (2014) Local renin-angiotensin system is associated with bone mineral density of glucocorticoid-induced osteoporosis patients. Osteoporosis International. 10.1007/s00198-014-2992-y
Hanxing Liu et al. (2022) Network Pharmacology and Molecular Docking-Based Mechanism Study to Reveal Antihypertensive Effect of Gedan Jiangya Decoction. Biomed Research International. 10.1155/2022/3353464
