Anti-ALK-1/ACVRL1 Antibody Picoband®

Overview

Anti-ALK-1/ACVRL1 Antibody Picoband® is an antibody for ACVRL1 detection raised in Rabbit (Polyclonal, Rabbit IgG), with reported reactivity: Human,Mouse,Rat. Commonly used in WB, IHC, Flow Cytometry, ELISA workflows.

Key elements and design rationale

• Target: ACVRL1 (glutathione S-transferase alpha 1/2/3/4/5); UniProt: P37023
• Antibody format: Rabbit, Polyclonal, Rabbit IgG
• Molecular weight: 55 kDa, calculated 25722 MW
• Applications: WB, IHC, Flow Cytometry, ELISA

Vendor description (summary): Boster Bio Anti-ALK-1/ACVRL1 Antibody Picoband® catalog # A01468-2.

Biological background

Biological context: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Expression and localization notes: cellular localization: Cytoplasm., tissue context: Liver..

Common research applications

• Western blotting (WB): Compare ACVRL1 levels across samples and conditions using appropriate loading and biological controls.
• Immunohistochemistry (IHC): Evaluate spatial distribution of ACVRL1 in tissue sections, considering fixation and antigen retrieval effects.
• Flow cytometry: Quantify ACVRL1-positive populations in single-cell suspensions with appropriate gating and controls.
• ELISA: Use antibody-based detection formats to assess antigen presence or binding in plate-based assays.

Notes for experimental interpretation

• Account for isoforms, post-translational modifications, and sample-specific processing that can shift apparent molecular weight or epitope accessibility.
• Use positive/negative biological controls where possible (e.g., known-expressing cells/tissues, knockdown/knockout models) and include appropriate secondary-only/isotype controls for imaging workflows.

Additional product notes (from provided fields)

• Background: Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ACVRL1 gene. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
• Cross reactivity: No cross-reactivity with other proteins
• Cellular localization: Cytoplasm.
• Tissue details: Liver.
• Research category: Epigenetics and Nuclear Signaling,Neurogenesis,Neurology Process,Neuroscience,Transcription

Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.