| Field | Specification |
|---|---|
| Target | |
| Alternative names | Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4; AQP4 |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human AQP4 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 17A30 is a rabbit monoclonal antibody that recognizes aquaporin-4 (gene AQP4) in human and rat samples and is validated for IHC. The predicted molecular weight is 34.8 kDa, and the supplier reports an observed band at about 35 kDa.
Aquaporin-4 (AQP4) is the main water channel of the brain, concentrated in astrocyte end-feet that surround blood vessels. It supports brain water balance and glymphatic fluid movement, and it is the target of autoantibodies in neuromyelitis optica, so it is widely studied in brain edema and neuroinflammation.
| Target | Aquaporin-4 (gene AQP4; UniProt P55087, human) |
|---|---|
| Clone | 17A30 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 34.8 kDa |
| Observed MW | 35 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Immunohistochemistry | 1:50–1:200 |
|---|
Immunogen
Synthetic peptide based on the sequence of human AQP4.
Reactivity Notes
The supplier lists reactivity with human and rat. UniProt places aquaporin-4 in the cell membrane, basolateral cell membrane, endosome membrane and cell projection. Tissue expression noted by UniProt (human): Detected in skeletal muscle.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
