| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Caspase-7;CASP-7;3.4.22.60;Apoptotic protease Mch-3;Cysteine protease LICE2;Caspase-7 subunit p20;Caspase-7 subunit p11;Casp7;Lice2, Mch3; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Form | Liquid |
| Host | |
| Immunogen | A synthesized peptide derived from human AQP4 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Storage | |
| Target | |
| UniProt # |
Overview
This product is an anti-AQP4 antibody for target detection and characterization. Key identifiers include host species: Rabbit; Monoclonal; clone 17A30; isotype IgG; reactivity: Human,Rat. Reported application contexts include IHC (as provided in the source record). Boster Bio Anti-AQP4 Rabbit Monoclonal Antibody catalog # M01049-1. Tested in IHC application. This antibody reacts with Human, Rat.
Key elements and design rationale
- Target: AQP4 (Caspase-7).
- Antibody format: Monoclonal; clone 17A30; isotype IgG.
- Host: Rabbit.
- Species reactivity: Human,Rat (confirm in your model system with appropriate controls).
This description is intended to help interpret the antibody design and the biological context of the target using the fields provided in the catalog record, alongside general experimental considerations.
Biological background
AQP4 (protein: Glycogen synthase kinase-3 beta (gsk3b)) is a commonly studied target in molecular and cellular biology. Functional context (as provided): Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Overexpression promotes programmed cell death (By similarity). . Reported cellular localization context: Cytoplasm. Tissue expression notes (as provided): Highly expressed in heart, lung, liver and kidney. Low levels in spleen, skeletal muscle and testis. No expression in the brain.
Research relevance and current trends
- Research context keywords from the source record include: Adaptive Immunity,B Cells,Cancer,Hematopoietic Progenitors,Immunoglobulins,Immunology,Lymphoid,Receptors,Stem Cells,Tumor Immunology.
- Current studies often focus on connecting target abundance/localization to pathway perturbations across models, tissues, and cell states.
- Quantitative and multiplexed assays (e.g., imaging + immunoblot panels) are commonly used to compare phenotypes across conditions and time-courses.
Common research applications
- Immunohistochemistry (IHC): evaluate spatial distribution of target-positive staining in tissue architecture.
Workflow ideas (metafield): Validate AQP4 antibody specificity using KO/KD control samples (WB/IF/IHC as appropriate), Detect AQP4 in FFPE tissue sections by immunohistochemistry, Compare relative AQP4 levels across experimental conditions (dose/time-course) using antibody-based readouts
Notes for experimental interpretation
- Consider isoforms and post-translational modifications (PTMs) that may shift apparent molecular weight or epitope accessibility.
- Apparent molecular weight may vary by sample type and processing (observed MW: 17 kDa; calculated MW: 34061 MW).
- Control concepts: include appropriate negative controls (e.g., isotype, KO/KD samples) and orthogonal validation when feasible.
Additional product details (from the source record)
- Molecular weight (observed): 17 kDa
- Cellular localization (provided): Cytoplasm.
- Tissue details (provided): Highly expressed in heart, lung, liver and kidney. Low levels in spleen, skeletal muscle and testis. No expression in the brain.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
