| Field | Specification |
|---|---|
| Target | |
| Alternative names | Transcription factor E2F1;E2F-1;PBR3;Retinoblastoma-associated protein 1;RBAP-1;Retinoblastoma-binding protein 3;RBBP-3;pRB-binding protein E2F-1;E2F1;RBBP3; |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human BMAL1 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 17A76 is a rabbit monoclonal antibody that recognizes basic helix-loop-helix ARNT-like protein 1 (gene BMAL1) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 68.8 kDa, and the supplier reports an observed band at about 68 kDa.
BMAL1 (also called ARNTL) is a bHLH-PAS transcription factor that forms a heterodimer with CLOCK or NPAS2 to activate E-box genes such as PER and CRY, which in turn repress BMAL1–CLOCK activity. This feedback loop is the core of the mammalian circadian clock, and BMAL1 is essential for circadian rhythms of behavior and metabolism.
| Target | Basic helix-loop-helix ARNT-like protein 1 (gene BMAL1; UniProt O00327, human) |
|---|---|
| Clone | 17A76 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 68.8 kDa |
| Observed MW | 68 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:2000–1:10000 |
|---|
Immunogen
Synthetic peptide based on the sequence of human BMAL1.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places basic helix-loop-helix ARNT-like protein 1 in the nucleus and cytoplasm. Tissue expression noted by UniProt (human): Hair follicles (at protein level).
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
