| Field | Specification |
|---|---|
| Target | |
| Alternative names | Bone morphogenetic protein 7;BMP-7;Osteogenic protein 1;OP-1;Eptotermin alfa;BMP7;OP1; |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human BMP7 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone AABH-2 is a rabbit monoclonal antibody that recognizes bone morphogenetic protein 7 (gene BMP7) in human, mouse and rat samples and is validated for Western blot and immunoprecipitation. The predicted molecular weight is 49.3 kDa, and the supplier reports an observed band at about 49 kDa.
Bone morphogenetic protein 7 (BMP7, also called OP-1) is a TGF-β superfamily growth factor that signals through BMP receptors and SMAD1/5/8. It is required for kidney and eye development and contributes to bone formation, and it is studied in brown fat development and as an antagonist of TGF-β-driven fibrosis.
| Target | Bone morphogenetic protein 7 (gene BMP7; UniProt P18075, human) |
|---|---|
| Clone | AABH-2 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 49.3 kDa |
| Observed MW | 49 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|---|
| Immunoprecipitation | 1:20 |
Samples with a confirmed band (WB): human fetal kidney.
Recommended loading (WB): 20–40 µg of total protein per lane.
Immunogen
Synthetic peptide based on the sequence of human BMP7.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt describes bone morphogenetic protein 7 as a secreted protein. Tissue expression noted by UniProt (human): Expressed in the kidney and bladder. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Hongyue Zhang et al. (2017) Bone morphogenetic protein-7 inhibits endothelial-mesenchymal transition in pulmonary artery endothelial cell under hypoxia. Journal of Cellular Physiology. 10.1002/jcp.26195
Hou-Qin Xiao et al. (2009) PODOCYTE INJURY IS SUPPRESSED BY 1,25-DIHYDROXYVITAMIN D3 VIA MODULATION OF TRANSFORMING GROWTH FACTOR-β1/BONE MORPHOGENETIC PROTEIN-7 SIGNALLING IN PUROMYCIN AMINONUCLEOSIDE NEPHROPATHY RATS. Clinical and Experimental Pharmacology and Physiology. 10.1111/j.1440-1681.2008.05133.x
Tu Qing-nian et al. (2011) Effects of panax notoginoside on the nephropathy in rats with type 1 diabetes mellitus. Chinese Journal of Integrative Medicine. 10.1007/s11655-011-0825-9
