| Field | Specification |
|---|---|
| Target | |
| Alternative names | Calpain-2 catalytic subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; Calpain large polypeptide L2; Calpain-2 large subunit; Millimolar-calpain; M-calpain; CAPN2; CANPL2 |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human Calpain 2 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 17C62 is a rabbit monoclonal antibody that recognizes calpain-2 catalytic subunit (gene CAPN2) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 80.0 kDa, and the supplier reports an observed band at about 80 kDa.
Calpain-2 (m-calpain) is a ubiquitous Ca2+-dependent cysteine protease that forms a heterodimer with CAPNS1. Through limited proteolysis of cytoskeletal and signaling substrates, it regulates focal adhesion turnover, cell migration and neuronal signaling, and it is studied in neurodegeneration, cancer and tissue injury.
| Target | Calpain-2 catalytic subunit (gene CAPN2; UniProt P17655, human) |
|---|---|
| Clone | 17C62 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 80.0 kDa |
| Observed MW | 80 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Immunogen
Synthetic peptide based on the sequence of human calpain 2.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places calpain-2 catalytic subunit in the cytoplasm and cell membrane. Tissue expression noted by UniProt (human): Ubiquitous.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
