| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Histone-lysine N-methyltransferase SETD7;2.1.1.43;Histone H3-K4 methyltransferase SETD7;H3-K4-HMTase SETD7;Lysine N-methyltransferase 7;SET domain-containing protein 7;SET7/9;SETD7;KIAA1717, KMT7, SET7, SET9; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human CD58 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-CD58 Rabbit Monoclonal Antibody catalog # M02800. Tested in WB, IP, Flow Cytometry applications. This antibody reacts with Human.
Protein: T-cell surface glycoprotein CD3 zeta chain | Gene: Histone-lysine N-methyltransferase SETD7 | Target: CD58 | Function: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. . | Research areas: Growth Factors/Hormones,Signal Transduction
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 26C99 | Isotype: IgG | Reactivity: Human | Immunogen: A synthesized peptide derived from human CD58 | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB, ICC, FC, IP
Observed MW: 50-75 kDa | Calculated MW: 40721 MW
Cellular localization: Nucleus. Chromosome .
Tissue details: Widely expressed. Expressed in pancreatic islets.
Status: Active
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