| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Macrosialin;Gp110;CD68;CD68; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human CD68 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-CD68/Sr D1 Rabbit Monoclonal Antibody is an antibody targeting CD68. Common applications include WB. Key specifications include host: Rabbit; clonality: Monoclonal; clone: Clone: GBE-3; isotype: Rabbit IgG; reactivity: Human,Mouse,Rat; observed MW: 32-42 kDa, 65 kDa, 75 kDa; calculated MW: 37408 MW.
Boster Bio Anti-CD68/Sr D1 Rabbit Monoclonal Antibody catalog # M00602-1. Tested in WB application. This antibody reacts with Human, Mouse, Rat.
Key elements and design rationale
- Target: CD68 — Macrosialin
- Antibody format: Host: Rabbit; Clonality: Monoclonal; Clone: Clone: GBE-3; Isotype: Rabbit IgG
- Species reactivity: Human,Mouse,Rat
- Molecular weight guidance: Observed: 32-42 kDa, 65 kDa, 75 kDa; Calculated: 37408 MW
Biological background
Protein function (datasheet): Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Cellular localization (datasheet): Isoform Short: Cell membrane; Single-pass type I membrane protein.
Tissue details (datasheet): Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. .
Research relevance and current trends
- Commonly studied in contexts related to Cell Type Markers,Immunology.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
