| Field | Specification |
|---|---|
| Target | |
| Alternative names | COP9 signalosome complex subunit 4; SGN4; Signalosome subunit 4; JAB1-containing signalosome subunit 4; COPS4; CSN4 |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human COPS4 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 28C07 is a rabbit monoclonal antibody that recognizes COP9 signalosome complex subunit 4 (gene COPS4) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 46.3 kDa, and the supplier reports an observed band at about 50 kDa.
COPS4 (CSN4) is a subunit of the COP9 signalosome, which regulates cullin-RING ubiquitin ligases by stripping NEDD8 from cullins. Through this activity the complex influences protein turnover, DNA damage responses and cell cycle progression, and COPS4 is studied in the ubiquitin–proteasome system.
| Target | COP9 signalosome complex subunit 4 (gene COPS4; UniProt Q9BT78, human) |
|---|---|
| Clone | 28C07 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 46.3 kDa |
| Observed MW | 50 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Samples with a confirmed band (WB): SH-SY5Y cells.
Recommended loading (WB): 20–40 µg of total protein per lane.
Immunogen
Synthetic peptide based on the sequence of human COPS4.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places COP9 signalosome complex subunit 4 in the cytoplasm and nucleus. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
