| Field | Specification |
|---|---|
| Target | |
| Alternative names | CREB3L2; BBF2H7; Cyclic AMP-responsive element-binding protein 3-like protein 2; cAMP-responsive element-binding protein 3-like protein 2; BBF2 human homolog on chromosome 7 [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human CREB3L2, which shares 95.7% and 100% amino acid (aa) sequence identity with mouse and rat CREB3L2, respectively. |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody recognizes cyclic AMP-responsive element-binding protein 3-like protein 2 (gene CREB3L2) in human samples and is validated for Western blot, IHC, ICC/IF and flow cytometry.
CREB3L2 (BBF2H7) is an ER membrane-bound transcription factor that is released by regulated intramembrane proteolysis during ER stress. It promotes genes of the secretory pathway, including SEC23A, and supports chondrocyte matrix secretion, so it is studied in the unfolded protein response and cartilage development.
| Target | Cyclic AMP-responsive element-binding protein 3-like protein 2 (gene CREB3L2; UniProt Q70SY1, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / Rabbit IgG |
| Reactivity | Human |
| Purification | Immunogen affinity purified |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4 |
| Reconstitution | 500 µg/mL after adding 0.2 mL distilled water |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.25–0.5 µg/mL (Human) |
|---|---|
| IHC (paraffin sections) | 2–5 µg/mL (Human) |
| Immunocytochemistry / Immunofluorescence | 5 µg/mL (Human) |
| Flow cytometry (fixed cells) | 1–3 µg/1×106 cells (Human) |
Conditions in the example images (IHC): heat-mediated antigen retrieval in EDTA buffer (pH 8.0).
Immunogen
Synthetic peptide from the N-terminal region of human CREB3L2. Sequence identity with the mouse and rat orthologs: 95.7% and 100%, respectively.
Reactivity Notes
The supplier lists reactivity with human. UniProt places cyclic AMP-responsive element-binding protein 3-like protein 2 in the endoplasmic reticulum membrane. Tissue expression noted by UniProt (human): Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
