| Field | Specification |
|---|---|
| Target | |
| Alternative names | Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog; XPO1; CRM1 |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human CRM1. |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone AEFD-24 is a rabbit monoclonal antibody that recognizes exportin-1 (gene XPO1) in human, mouse and rat samples and is validated for Western blot, IHC, ICC/IF and flow cytometry. The predicted molecular weight is 123.4 kDa, and the supplier reports an observed band at about 110 kDa.
Exportin-1 (XPO1, also called CRM1) is the major nuclear export receptor for proteins bearing leucine-rich nuclear export signals. Loaded with cargo in the nucleus in a Ran-GTP-dependent manner, it moves through nuclear pores and releases cargo in the cytoplasm, and it exports many tumor suppressors, certain RNAs and viral proteins such as HIV-1 Rev, making it a target of selective inhibitors in cancer research.
| Target | Exportin-1 (gene XPO1; UniProt O14980, human) |
|---|---|
| Clone | AEFD-24 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 123.4 kDa |
| Observed MW | 110 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|---|
| Immunohistochemistry | 1:50–1:200 |
| Immunocytochemistry / Immunofluorescence | 1:50–1:200 |
| Flow cytometry | 1:100 |
Immunogen
Synthetic peptide based on the sequence of human CRM1.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places exportin-1 in the cytoplasm and nucleus. Tissue expression noted by UniProt (human): Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
