| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Advanced glycosylation end product-specific receptor;Receptor for advanced glycosylation end products;AGER;RAGE; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human CTR1/SLC31A1 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-CTR1/SLC31A1 Rabbit Monoclonal Antibody catalog # M03447. Tested in WB application. This antibody reacts with Human, Mouse, Rat.
Protein: T-cell surface glycoprotein CD3 zeta chain | Gene: Advanced glycosylation end product-specific receptor | Target: SLC31A1 | Function: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. . | Research areas: Adapters,Cytoskeleton,Cytoskeleton/ECM,Motor Proteins,Neuroscience,Neurotransmitter,Protein Trafficking,Signal Transduction,Signaling Pathways,Stem Cells,Surface Molecules,Transporters,Vesicle Transport
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 26S95 | Isotype: IgG | Reactivity: Human,Mouse,Rat | Immunogen: A synthesized peptide derived from human CTR1/SLC31A1 | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB
Observed MW: 29 kDa | Calculated MW: 42803 MW
Cellular localization: Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue details: Endothelial cells.
Status: Active
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