| Field | Specification |
|---|---|
| Target | |
| Alternative names | Tumor necrosis factor receptor superfamily member 10B;Death receptor 5;TNF-related apoptosis-inducing ligand receptor 2;TRAIL receptor 2;TRAIL-R2;CD262;TNFRSF10B;DR5, KILLER, TRAILR2, TRICK2, ZTNFR9;UNQ160/PRO186; |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human DR5 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone ABFC-20 is a rabbit monoclonal antibody that recognizes tumor necrosis factor receptor superfamily member 10B (gene TNFRSF10B) in human samples and is validated for Western blot, immunoprecipitation and flow cytometry. The predicted molecular weight is 47.9 kDa; the supplier reports observed bands at 40, 48 kDa.
TRAIL-R2 (TNFRSF10B, DR5) is a death receptor for the cytokine TRAIL. After ligand binding, FADD and caspase-8 assemble into a death-inducing signaling complex that activates caspases and apoptosis, and DR5 is also induced by p53 and ER stress. TRAIL-R2 is studied in apoptosis, cancer cell killing and stress-induced cell death.
| Target | Tumor necrosis factor receptor superfamily member 10B (gene TNFRSF10B; UniProt O14763, human) |
|---|---|
| Clone | ABFC-20 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 47.9 kDa |
| Observed MW | 40, 48 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|---|
| Immunoprecipitation | 1:20 |
| Flow cytometry | 1:20 |
Immunogen
Synthetic peptide based on the sequence of human DR5.
Reactivity Notes
The supplier lists reactivity with human. UniProt places tumor necrosis factor receptor superfamily member 10B in the membrane. Tissue expression noted by UniProt (human): Widely expressed in adult and fetal tissues.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
