| Field | Specification |
|---|---|
| Target | |
| Alternative names | D (1A) dopamine receptor;Dopamine D1 receptor;DRD1; |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human DRD1 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone AAEA-4 is a rabbit monoclonal antibody that recognizes dopamine receptor D1 (gene DRD1) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 49.3 kDa, and the supplier reports an observed band at about 75 kDa.
Dopamine receptor D1 (DRD1) is the most abundant dopamine receptor in the brain and a G protein-coupled receptor of the D1 class. It couples to Gs to stimulate adenylyl cyclase and cAMP production, and in the striatum and cortex it shapes reward, movement and cognition, making it a key target in neuropharmacology.
| Target | Dopamine receptor D1 (gene DRD1; UniProt P21728, human) |
|---|---|
| Clone | AAEA-4 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 49.3 kDa |
| Observed MW | 75 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Samples with a confirmed band (WB): SH-SY5Y cells, mouse kidney.
Recommended loading (WB): 20–40 µg of total protein per lane.
Immunogen
Synthetic peptide based on the sequence of human DRD1.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places dopamine receptor D1 in the postsynaptic cell membrane, cell projection and endoplasmic reticulum membrane. Tissue expression noted by UniProt (human): Detected in caudate, nucleus accumbens and in the olfactory tubercle. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Ma Yongkang et al. (2026) The influence of HINT1 protein in nucleus accumbens on aggressive behavior and anxiety-like behavior. Psychopharmacology. 10.1007/s00213-026-07102-y
