| Field | Specification |
|---|---|
| Target | |
| Alternative names | Endothelin receptor type B; ET-B; ET-BR; Endothelin receptor non-selective type; EDNRB; ETRB |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E.coli-derived human EDNRB recombinant protein (Position: E27-Y439). Human EDNRB shares 89.9% amino acid (aa) sequence identity with both mouse and rat EDNRB. |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody recognizes endothelin receptor type B (gene EDNRB) in human samples and is validated for Western blot, flow cytometry and ELISA.
Endothelin receptor type B (EDNRB) is a G protein-coupled receptor that binds all three endothelins with similar affinity. It mediates vasodilation and clearance of endothelin-1 and is needed for development of enteric neurons and melanocytes, so its loss is linked to Hirschsprung disease.
| Target | Endothelin receptor type B (gene EDNRB; UniProt P24530, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / IgG |
| Reactivity | Human |
| Purification | Immunogen affinity purified |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4 |
| Reconstitution | 500 µg/mL after adding 0.2 mL distilled water |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.25–0.5 µg/mL (Human) |
|---|---|
| ELISA | 0.1–0.5 µg/mL |
| Flow cytometry | Not specified by the supplier |
Immunogen
Recombinant human EDNRB fragment (Glu27–Tyr439), expressed in E. coli. Sequence identity with the mouse and rat orthologs: 89.9%.
Reactivity Notes
The supplier lists reactivity with human. UniProt places endothelin receptor type B in the cell membrane. Tissue expression noted by UniProt (human): Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
