| Field | Specification |
|---|---|
| Target | |
| Alternative names | Guanidinoacetate N-methyltransferase; GAMT |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E.coli-derived human GAMT recombinant protein (Position: M1-G236). Human GAMT shares 88.1% and 86.8% amino acid (aa) sequence identity with mouse and rat GAMT. |
| Purification | |
| Reconstitution | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody recognizes guanidinoacetate N-methyltransferase (gene GAMT) in human, mouse and rat samples and is validated for Western blot and ELISA.
Guanidinoacetate N-methyltransferase (GAMT) catalyzes the final step of creatine synthesis, methylating guanidinoacetate with S-adenosylmethionine as the methyl donor. It is expressed mainly in liver. GAMT deficiency is an inherited creatine deficiency syndrome that affects brain development.
| Target | Guanidinoacetate N-methyltransferase (gene GAMT; UniProt Q14353, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Purification | Immunogen affinity purified |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4 |
| Reconstitution | 500 µg/mL after adding 0.2 mL distilled water |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.25–0.5 µg/mL (Human, Mouse, Rat) |
|---|---|
| ELISA | 0.1–0.5 µg/mL |
Immunogen
Recombinant human GAMT fragment (Met1–Gly236), expressed in E. coli. Sequence identity with the mouse and rat orthologs: 88.1% and 86.8%, respectively.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. Tissue expression noted by UniProt (human): Expressed in liver.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Wang Yingwen et al. (2026) MO-IPS suppresses acute myeloid leukemia through metabolic reprogramming and synergizes with anti-PD-1 immunotherapy. Functional & Integrative Genomics. 10.1007/s10142-026-01943-8
