| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | BEC2 |
| Cas No. | |
| Clonality | |
| Expression System | |
| Form | Liquid |
| Host | |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
Mitumomab (YP464026) is a research-grade recombinant antibody targeting Ganglioside GD3. Produced in mammalian cells with native-like glycosylation. Highlights- ●Research Grade — For PK/PD studies, assay development, and ADA research.
- ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Specifications
| Host Species | Mouse |
|---|---|
| Species Reactivity | General |
| Clonality | Monoclonal |
| Isotype | IgG2b, kappa |
| Target | Ganglioside GD3 |
| Purification | Protein A/G purified from cell culture supernatant. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Form | Liquid |
| Storage Buffer | 0.01M PBS, pH 7.4. |
| Expression System | Mammalian Cells |
Validated Applications
| Application |
|---|
| ELISA |
| Flow Cytometry |
| Functional Assay |
| In Vivo Studies |
Scientific Background
Mitumomab is an anti-idiotypic mouse IgG2b monoclonal antibody that mimics the ganglioside GD3. Mitumomab can be used for the research of small-cell lung carcinoma.• GD3 ganglioside and apoptosis., PMID:12531552
• Ganglioside GD3: structure, cellular distribution, and possible function., PMID:3903474
• Ganglioside GD3 as a raft component in cell death regulation., PMID:21554197
• A reappraisal of ganglioside GD3 expression in the CNS., PMID:8721669
• Ganglioside GD3 regulates neural stem cell quiescence and controls postnatal neurogenesis., PMID:37667994
• Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia., PMID:34133773
• Ganglioside GD3 regulates dendritic growth in newborn neurons in adult mouse hippocampus via modulation of mitochondrial dynamics., PMID:32743804
• Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells., PMID:36897478
• Ganglioside GD3 Regulates Inflammation and Epithelial-to-Mesenchymal Transition in Human Nasal Epithelial Cells., PMID:38612859
• Development of Fluorescent Ganglioside GD3 and GQ1b Analogs for Elucidation of Raft-Associated Interactions., PMID:32951428
Reactivity
This antibody shows reactivity with General.
Safety & Handling
Customization & Add-ons: Can't find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
• GD3 ganglioside and apoptosis., PMID: 12531552
• Ganglioside GD3: structure, cellular distribution, and possible function., PMID: 3903474
• Ganglioside GD3 as a raft component in cell death regulation., PMID: 21554197
• A reappraisal of ganglioside GD3 expression in the CNS., PMID: 8721669
• Ganglioside GD3 regulates neural stem cell quiescence and controls postnatal neurogenesis., PMID: 37667994
• Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia., PMID: 34133773
• Ganglioside GD3 regulates dendritic growth in newborn neurons in adult mouse hippocampus via modulation of mitochondrial dynamics., PMID: 32743804
• Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells., PMID: 36897478
• Ganglioside GD3 Regulates Inflammation and Epithelial-to-Mesenchymal Transition in Human Nasal Epithelial Cells., PMID: 38612859
• Development of Fluorescent Ganglioside GD3 and GQ1b Analogs for Elucidation of Raft-Associated Interactions., PMID: 32951428
