Anti-HNF-4-alpha Rabbit Monoclonal Antibody

Boster Bio Anti-HNF-4-alpha Rabbit Monoclonal Antibody catalog # M00389-3. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.

Protein: T-cell surface glycoprotein CD4 | Gene: Hepatocyte nuclear factor 4-alpha | Target: HNF4A | Function: Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine. | Research areas: Cancer,DNA/RNA,DNA Damage & Repair,Epigenetics and Nuclear Signaling,Tumor Biomarkers

Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 28H19 | Isotype: IgG | Reactivity: Human,Mouse,Rat | Immunogen: A synthesized peptide derived from human HNF-4-alpha | Concentration: 0.5mg/ml | Purification: Affinity-chromatography

Applications: WB, IHC, IP

Observed MW: 53 kDa | Calculated MW: 52785 MW

Cellular localization: Nucleus.

Tissue details: Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers. .

Status: Active

Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.