| Field | Specification |
|---|---|
| Mfr No | |
| Cas No. | |
| Clonality | |
| Form | Liquid |
| Host | |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Reconstitution | |
| Storage | |
| Target | |
| UniProt # |
Product Overview
zadoprubart (HV375066) is a research-grade recombinant antibody targeting CD272. Highlights- ●Research Grade — For PK/PD studies, assay development, and ADA research.
Specifications
| Host Species | Human |
|---|---|
| Species Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | IgG4, kappa |
| Target | CD272/BTLA |
| Purity | >95% purity as determined by SDS-PAGE. |
| Form | Liquid |
| UniProt | Q7Z6A9 |
Validated Applications
| Application |
|---|
| ELISA |
| Flow Cytometry |
| Functional Assay |
| In Vivo Studies |
Scientific Background
B- and T-lymphocyte attenuator (CD272/BTLA) is a ~32 kDa protein. Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2.
Reactivity
This antibody shows reactivity with Human.
Safety & Handling
Customization & Add-ons: Can't find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
1. Watanabe, N. et al. (2003) Nature immunology 4, 670-9. PMID: 12796776
2. Gavrieli, M. et al. (2003) Biochem Biophys Res Commun 312, 1236-43. PMID: 14652006
3. Sedy, JR. et al. (2005) Nature immunology 6, 90-8. PMID: 15568026
4. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050
5. Cheung, TC. et al. (2009) Journal of immunology 183, 7286-96. PMID: 19915044
