| Field | Specification |
|---|---|
| Target | |
| Alternative names | Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221; IGF1R |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E.coli-derived human IGF1R recombinant protein (Position: Q44-R960). Human IGF1R shares 95.9% and 95.8% amino acid (aa) sequence identity with mouse and rat IGF1R, respectively. |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody targets insulin-like growth factor 1 receptor (gene IGF1R) in human samples and is validated for Western blot and ELISA.
The IGF-1 receptor (IGF1R) is a receptor tyrosine kinase that binds IGF-1 with high affinity and IGF-2 and insulin more weakly. Ligand binding triggers autophosphorylation and recruitment of adaptors such as IRS proteins and SHC, activating the PI3K-AKT and MAPK pathways that drive growth and survival, which makes IGF1R a focus of growth and cancer research.
| Target | Insulin-like growth factor 1 receptor (gene IGF1R; UniProt P08069, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / IgG |
| Reactivity | Human |
| Purification | Immunogen affinity purified |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4 |
| Reconstitution | 500 µg/mL after adding 0.2 mL distilled water |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.25–0.5 µg/mL (Human) |
|---|---|
| ELISA | 0.1–0.5 µg/mL |
Immunogen
Recombinant human IGF1R fragment (Gln44–Arg960), expressed in E. coli. Sequence identity with the mouse and rat orthologs: 95.9% and 95.8%, respectively.
Reactivity Notes
The supplier lists reactivity with human. UniProt places insulin-like growth factor 1 receptor in the cell membrane. Tissue expression noted by UniProt (human): Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level).
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
