| Field | Specification |
|---|---|
| Target | |
| Alternative names | Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; Placental protein 12; PP12; IGFBP1; IBP1 |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human IGFBP1 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 22I68 is a rabbit monoclonal antibody that recognizes insulin-like growth factor-binding protein 1 (gene IGFBP1) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 27.9 kDa, and the supplier reports an observed band at about 35 kDa.
IGFBP-1 is a secreted insulin-like growth factor binding protein produced mainly by the liver and by decidualized endometrium. It binds IGF-1 and IGF-2 and controls their access to receptors, with levels acutely regulated by insulin and nutritional state, and it can also signal through integrin α5β1 to promote cell migration.
| Target | Insulin-like growth factor-binding protein 1 (gene IGFBP1; UniProt P08833, human) |
|---|---|
| Clone | 22I68 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 27.9 kDa |
| Observed MW | 35 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Immunogen
Synthetic peptide based on the sequence of human IGFBP1.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt describes insulin-like growth factor-binding protein 1 as a secreted protein.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Tang L et al. (2016) MicroRNA-145 functions as a tumor suppressor by targeting matrix metalloproteinase 11 and Rab GTPase family 27a in triple-negative breast cancer. Cancer Gene Therapy. 10.1038/cgt.2016.27
