| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Ribonuclease 3;3.1.26.3 ;Protein Drosha ;Ribonuclease III;RNase III;p241;DROSHA;RN3, RNASE3L, RNASEN; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human IL-33 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-IL-33 Rabbit Monoclonal Antibody catalog # M00113-2. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Mouse, Rat.
Protein: P2X purinoceptor 1 | Gene: Ribonuclease 3 | Target: Il33 | Function: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double- strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. . | Research areas: 2339,DNA/RNA,Epigenetics and Nuclear Signaling,Nuclear Receptors,Nuclear Signaling Pathways,RNA Processing
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 28I14 | Isotype: IgG | Reactivity: Mouse,Rat | Immunogen: A synthesized peptide derived from human IL-33 | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB, IHC, IF, ICC
Observed MW: 31 kDa | Calculated MW: 159316 MW
Cellular localization: Nucleus . Nucleus, nucleolus . A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. .
Tissue details: Ubiquitous. .
Status: Active
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