| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C30H24Cl2N2O4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Anti-inflammatory agent 40 is an orally active, potential anti-malarial and anti-inflammatory agent. It inhibits carrageenan-induced paw swelling in vivo. It has a molecular formula of C30H24Cl2N2O4 and a molecular weight of 547.43 g/mol.
Physical & Chemical Properties
| CAS Number | 3043821-37-7 |
|---|---|
| Molecular Formula | C30H24Cl2N2O4 |
| Molecular Weight | 547.43 g/mol |
| SMILES | CC1=C(C(C2=CC=C(C=C2)Cl)=C(N1CCC3=CC(OC3O)=O)C4=CC=C(C=C4)Cl)C(NC5=CC=CC=C5)=O |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Anti-inflammatory agent 40 is active against both CQ-sensitive and resistant strains of P. falciparum, with an IC50 of 1.47 μM against the chloroquine-sensitive strain of P. falciparum (Pf3D7)[1]. In THP-1 monocytes, Anti-inflammatory agent 40 inhibits LPS-induced MAP kinase activation and lowers the expression of pERK1/2 (Thr202/Tyr204) and pJNK1/2[1].
In Vivo
In Swiss mice, Anti-inflammatory agent 40 is given p.o. 1 h before carrageenan injection at 25, 50 and 100 mg/kg, and paw swelling is then monitored at 4 and 6 h. Carrageenan inhibition is 61% and 56% at 25 mg/kg after 4 h and 6 h, respectively; 62% and 56% at 50 mg/kg after 4 h and 6 h, respectively; and 73% and 65% at 100 mg/kg after 4 h and 6 h, respectively[1]. The PK profile of Anti-inflammatory agent 40 is good and satisfactory, supporting it as a candidate for future drug discovery optimization; the measured values are Cmax 110.37 ± 11.92 ng/mL, Tmax 0.25 ± 0.0 h, AUC 86.91 ± 16.86 h.ng/mL, and t1/2 0.87 ± 0.15 h[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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