| Field | Specification |
|---|---|
| Target | |
| Alternative names | Immunity-related GTPase family Q protein; IRGQ; IRGQ1 |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E.coli-derived human IRGQ recombinant protein (Position: D7-Q623). Human IRGQ shares 78.2% amino acid (aa) sequence identity with mouse IRGQ. |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody recognizes immunity-related GTPase family Q protein (gene IRGQ) in human samples and is validated for Western blot, flow cytometry and ELISA.
IRGQ is an immunity-related GTPase family protein that lacks GTPase activity. It acts as an autophagy receptor that directs misfolded MHC class I molecules to lysosomes for degradation, which influences how much MHC class I reaches the cell surface and how strongly T cells respond.
| Target | Immunity-related GTPase family Q protein (gene IRGQ; UniProt Q8WZA9, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / IgG |
| Reactivity | Human |
| Purification | Immunogen affinity purified |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4 |
| Reconstitution | 500 µg/mL after adding 0.2 mL distilled water |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.25–0.5 µg/mL (Human) |
|---|---|
| Flow cytometry (fixed cells) | 1–3 µg/1×106 cells (Human) |
| ELISA | 0.1–0.5 µg/mL |
Immunogen
Recombinant human IRGQ fragment (Asp7–Gln623), expressed in E. coli. Sequence identity with the mouse ortholog: 78.2%.
Reactivity Notes
The supplier lists reactivity with human. UniProt places immunity-related GTPase family Q protein in the lysosome and cytoplasmic vesicle.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
