| Field | Specification |
|---|---|
| Target | |
| Alternative names | Lysosome-associated membrane glycoprotein 1;LAMP-1;Lysosome-associated membrane protein 1;CD107 antigen-like family member A;CD107a;LAMP1; |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human LAMP1 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone IIB-12 is a rabbit monoclonal antibody that recognizes lysosome-associated membrane glycoprotein 1 (gene LAMP1) in human samples and is validated for Western blot and IHC. The predicted molecular weight is 44.9 kDa, and the supplier reports an observed band at about 100–130 kDa.
LAMP1 (CD107a) is a heavily glycosylated membrane protein that lines the lysosome and is one of the most widely used lysosomal markers. It supports lysosome biogenesis, acidification and autophagy, in part by restraining the proton channel TMEM175. In NK cells and cytotoxic T cells it appears on the surface after degranulation, so CD107a staining is a standard readout of cytotoxic activity.
| Target | Lysosome-associated membrane glycoprotein 1 (gene LAMP1; UniProt P11279, human) |
|---|---|
| Clone | IIB-12 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 44.9 kDa |
| Observed MW | 100–130 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|---|
| Immunohistochemistry | 1:50–1:200 |
Immunogen
Synthetic peptide based on the sequence of human LAMP1.
Reactivity Notes
The supplier lists reactivity with human. UniProt places lysosome-associated membrane glycoprotein 1 in the lysosome membrane, endosome membrane, late endosome membrane and cell membrane.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Tuying Yong et al. (2016) Domino-Like Intercellular Delivery of Undecylenic Acid-Conjugated Porous Silicon Nanoparticles for Deep Tumor Penetration. ACS Applied Materials & Interfaces. 10.1021/acsami.6b11127
Xianbin Huang et al. (2026) KNSTRN knockdown impairs autophagy flux to inhibit bladder cancer progression. iScience. 10.1016/j.isci.2026.114734
