| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Lysyl oxidase homolog 1;1.4.3.-;Lysyl oxidase-like protein 1;LOL;LOXL1;LOXL; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human LOXL1, different from the related mouse sequence by one amino acid. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
This antibody is intended for detection of LOXL1 (Lysyl oxidase homolog 1) in biological samples using common immunoassay formats. It is typically selected based on target identity, species reactivity, clonality/clone information, and detection modality.
Vendor notes: Boster Bio Anti-LOXL1 Antibody Picoband® catalog # PB9719. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key elements and design rationale
- Antibody format: Rabbit Polyclonal Rabbit IgG
- Immunogen / epitope context: A synthetic peptide corresponding to a sequence at the C-terminus of human LOXL1, different from the related mouse sequence by one amino acid.
- Molecular weight context: reported MW: 63 kDa; calculated MW: 63110 MW
- Reactivity: Human
- Applications: IHC, WB
As a polyclonal antibody, the reagent recognizes multiple epitopes on the target, which can improve detection robustness but may increase sensitivity to sample-dependent epitope changes.
Biological background
Lysyl oxidase homolog 1; Lysyl oxidase homolog 1. Lysyl oxidase homolog 1, also known as?LOXL1, is an?enzyme?which in humans is encoded by the?LOXL1?gene. This gene encodes a member of the?lysyl oxidase?gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in?collagens?and?elastin. A highly conserved amino acid sequence at the C-terminus?end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The?N-terminus?is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and?chemotaxis?to each member of the family. Functional note: Active on elastin and collagen substrates. . Reported localization: Secreted, extracellular space . Expression/tissue context: Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina. .
Research relevance and current trends
- Amino Acid Metabolism: Researchers commonly examine how LOXL1 (Lysyl oxidase homolog 1) relates to this theme using model systems and orthogonal readouts.
- Amino Acids: Researchers commonly examine how LOXL1 (Lysyl oxidase homolog 1) relates to this theme using model systems and orthogonal readouts.
- Cancer: Researchers commonly examine how LOXL1 (Lysyl oxidase homolog 1) relates to this theme using model systems and orthogonal readouts.
Common research applications
- Western blotting: compare relative LOXL1 (Lysyl oxidase homolog 1) levels across conditions; band patterns may reflect isoforms and processing.
- IHC/IHC-F: assess spatial distribution of LOXL1 (Lysyl oxidase homolog 1) across tissue regions and cell types using matched controls.
Notes for experimental interpretation
- Specificity notes: No cross reactivity with other proteins.
- Cross-reactivity: No cross-reactivity with other proteins
- Isoforms and PTMs: Apparent size and signal patterns can differ across splice isoforms, proteolytic processing, and post-translational modifications.
- Controls: Include an isotype control (as relevant), no-primary control for imaging, and orthogonal validation such as KD/KO samples when available.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
