| Field | Specification |
|---|---|
| Target | |
| Alternative names | Lysyl oxidase homolog 2; Lysyl oxidase-like protein 2; Lysyl oxidase-related protein 2; Lysyl oxidase-related protein WS9-14; LOXL2 |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human LOXL2 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone ADBD-12 is a rabbit monoclonal antibody that recognizes lysyl oxidase homolog 2 (gene LOXL2) in human, mouse and rat samples and is validated for Western blot, ICC/IF and flow cytometry. The predicted molecular weight is 86.7 kDa; the supplier reports observed bands at 53, 106 kDa.
Lysyl oxidase-like 2 (LOXL2) is a copper-dependent amine oxidase that cross-links collagen and elastin in the extracellular matrix. Inside the nucleus it can also oxidize trimethylated histone H3 lysine 4 and act as a transcriptional corepressor, including in epithelial–mesenchymal transition. LOXL2 is studied in fibrosis, tissue stiffness and tumor progression.
| Target | Lysyl oxidase homolog 2 (gene LOXL2; UniProt Q9Y4K0, human) |
|---|---|
| Clone | ADBD-12 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 86.7 kDa |
| Observed MW | 53, 106 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|---|
| Immunocytochemistry / Immunofluorescence | 1:50–1:200 |
| Flow cytometry | 1:20 |
Immunogen
Synthetic peptide based on the sequence of human LOXL2.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places lysyl oxidase homolog 2 in the nucleus, chromosome and endoplasmic reticulum. Tissue expression noted by UniProt (human): Expressed in many tissues.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
