| Field | Specification |
|---|---|
| Target | |
| Alternative names | Cell growth-regulating nucleolar protein; LYAR |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E.coli-derived human LYAR recombinant protein (Position: M1-K379). Human LYAR shares 71.9% |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody detects cell growth-regulating nucleolar protein (gene LYAR) in human, mouse and rat samples and is validated for Western blot, ICC/IF, immunoprecipitation and ELISA.
LYAR is a nucleolar zinc finger protein involved in processing precursor ribosomal RNA into mature 18S and 28S rRNAs. It also has transcriptional roles, including repressing fetal gamma-globin genes together with PRMT5, and has been reported to restrain IRF3- and NF-κB-driven antiviral and inflammatory responses, so it is studied in ribosome biogenesis and globin switching.
| Target | Cell growth-regulating nucleolar protein (gene LYAR; UniProt Q9NX58, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Purification | Immunogen affinity purified |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4 |
| Reconstitution | 500 µg/mL after adding 0.2 mL distilled water |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.1–0.25 µg/mL (Human, Mouse, Rat) |
|---|---|
| Immunoprecipitation | 0.5–2 µg/mL (Human) |
| Immunocytochemistry / Immunofluorescence | 5 µg/mL (Human) |
| ELISA | 0.1–0.5 µg/mL |
Immunogen
Recombinant human LYAR fragment (Met1–Lys379), expressed in E. coli.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places cell growth-regulating nucleolar protein in the nucleus and cytoplasm. Tissue expression noted by UniProt (human): Predominantly expressed in testis.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
