| Field | Specification |
|---|---|
| Target | |
| Alternative names | Meckelin; Meckel syndrome type 3 protein; Transmembrane protein 67; TMEM67; MKS3 |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human Meckelin |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 30T77 is a rabbit monoclonal antibody that recognizes meckelin (gene TMEM67) in human, mouse and rat samples and is validated for Western blot, IHC, ICC/IF and flow cytometry. The predicted molecular weight is 111.7 kDa, and the supplier reports an observed band at about 120 kDa.
Meckelin (TMEM67) is a transmembrane protein of the ciliary transition zone that helps build and maintain primary cilia. It takes part in positioning the centrosome at the apical surface during ciliogenesis and in controlling the protein content of the ciliary membrane. TMEM67 mutations cause Meckel and Joubert syndromes and related ciliopathies.
| Target | Meckelin (gene TMEM67; UniProt Q5HYA8, human) |
|---|---|
| Clone | 30T77 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 111.7 kDa |
| Observed MW | 120 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|---|
| Immunohistochemistry | 1:50–1:200 |
| Immunocytochemistry / Immunofluorescence | 1:50–1:200 |
| Flow cytometry | 1:50 |
Immunogen
Synthetic peptide based on the sequence of human meckelin.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places meckelin in the cell membrane, endoplasmic reticulum membrane and cell projection. Tissue expression noted by UniProt (human): Widely expressed in adult and fetal tissues.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
