| Field | Specification |
|---|---|
| Target | |
| Alternative names | Metabotropic glutamate receptor 1;mGluR1;GRM1;GPRC1A, MGLUR1; |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human mGluR1 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone IGI-7 is a rabbit monoclonal antibody that recognizes metabotropic glutamate receptor 1 (gene GRM1) in human, mouse and rat samples and is validated for Western blot and IHC. The predicted molecular weight is 132.4 kDa, and the supplier reports an observed band at about 101 kDa.
Metabotropic glutamate receptor 1 (mGluR1, GRM1) is a group I G protein-coupled receptor that couples through Gq proteins to phospholipase C, inositol phosphate production and intracellular Ca2+ release. It is highly expressed in cerebellar Purkinje cells and contributes to long-term depression and motor coordination, so it is studied in synaptic plasticity and neurological disorders.
| Target | Metabotropic glutamate receptor 1 (gene GRM1; UniProt Q13255, human) |
|---|---|
| Clone | IGI-7 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 132.4 kDa |
| Observed MW | 101 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|---|
| Immunohistochemistry | 1:50–1:200 |
Samples with confirmed staining (IHC): mouse brain tissue, rat brain tissue.
Recommended antigen retrieval: heat-mediated, in TE buffer (pH 9.0); citrate buffer (pH 6.0) can be used instead.
Conditions in the example images (IHC): heat-mediated antigen retrieval in EDTA buffer (pH 8.0).
Immunogen
Synthetic peptide based on the sequence of human mGluR1.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places metabotropic glutamate receptor 1 in the cell membrane, postsynaptic cell membrane and cell projection. Tissue expression noted by UniProt (human): Detected in brain. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
