| Field | Specification |
|---|---|
| Target | |
| Alternative names | Metabotropic glutamate receptor 2;mGluR2;GRM2;GPRC1B, MGLUR2; |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human mGluR2 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone IEI-7 is a rabbit monoclonal antibody that recognizes metabotropic glutamate receptor 2 (gene GRM2) in human, mouse and rat samples and is validated for Western blot, IHC and ICC/IF. The predicted molecular weight is 95.6 kDa; the supplier reports observed bands at 95, 200 kDa.
Metabotropic glutamate receptor 2 (mGluR2, GRM2) is a group II G protein-coupled receptor that forms dimers and signals through Gi/o proteins to inhibit adenylyl cyclase. Located largely on presynaptic terminals, it limits further glutamate release when glutamate levels rise, dampening excitatory transmission. mGluR2 is a research focus in synaptic regulation, anxiety and schizophrenia models.
| Target | Metabotropic glutamate receptor 2 (gene GRM2; UniProt Q14416, human) |
|---|---|
| Clone | IEI-7 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 95.6 kDa |
| Observed MW | 95, 200 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:1000–1:5000 |
|---|---|
| Immunohistochemistry | 1:50–1:200 |
| Immunocytochemistry / Immunofluorescence | 1:50–1:200 |
Immunogen
Synthetic peptide based on the sequence of human mGluR2.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places metabotropic glutamate receptor 2 in the cell membrane, synapse and cell projection. Tissue expression noted by UniProt (human): Detected in brain cortex (at protein level).
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
