| Field | Specification |
|---|---|
| Target | |
| Alternative names | Sphingolipid delta; 4; -desaturase DES1; Cell migration-inducing gene 15 protein; Degenerative spermatocyte homolog 1; Dihydroceramide desaturase-1; Membrane lipid desaturase; Retinol isomerase; DEGS1; DES1; MLD |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human MLD |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 30D03 is a rabbit monoclonal antibody that recognizes sphingolipid delta(4)-desaturase DES1 (gene DEGS1) in human samples and is validated for Western blot. The predicted molecular weight is 37.9 kDa, and the supplier reports an observed band at about 34 kDa.
DEGS1 (dihydroceramide desaturase 1) inserts a double bond into the sphingoid backbone of dihydroceramide to make ceramide, the final step of de novo ceramide synthesis. This step controls the balance between dihydroceramides and ceramides, lipids with different signaling properties. DEGS1 is studied in sphingolipid metabolism, metabolic disease and myelin biology.
| Target | Sphingolipid delta(4)-desaturase DES1 (gene DEGS1; UniProt O15121, human) |
|---|---|
| Clone | 30D03 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 37.9 kDa |
| Observed MW | 34 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Immunogen
Synthetic peptide based on the sequence of human MLD.
Reactivity Notes
The supplier lists reactivity with human. UniProt places sphingolipid delta(4)-desaturase DES1 in the mitochondrion membrane and endoplasmic reticulum membrane. Tissue expression noted by UniProt (human): Ubiquitous.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
