| Field | Specification |
|---|---|
| Target | |
| Alternative names | Double-strand break repair protein MRE11A;Meiotic recombination 11 homolog 1;MRE11 homolog 1;Meiotic recombination 11 homolog A;MRE11 homolog A;MRE11A;HNGS1, MRE11; |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human Mre11 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone AAGG-13 is a rabbit monoclonal antibody that recognizes double-strand break repair protein MRE11 in human, mouse and rat samples and is validated for Western blot and IHC. The predicted molecular weight is 80.6 kDa, and the supplier reports an observed band at about 81 kDa.
MRE11 is a nuclease that, with RAD50 and NBS1, forms the MRN complex, one of the first responders to DNA double-strand breaks. MRN processes broken DNA ends to start homologous recombination and helps activate the ATM kinase, so MRE11 is studied in DNA repair, telomere maintenance and meiosis.
| Target | Double-strand break repair protein MRE11 (gene MRE11; UniProt P49959, human) |
|---|---|
| Clone | AAGG-13 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 80.6 kDa |
| Observed MW | 81 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|---|
| Immunohistochemistry | 1:50–1:200 |
Samples with a confirmed band (WB): K562 cells.
Recommended loading (WB): 20–40 µg of total protein per lane.
Immunogen
Synthetic peptide based on the sequence of human mre11.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places double-strand break repair protein MRE11 in the nucleus and chromosome. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Fei Peng et al. (2026) Engineered Bacteria-Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity. Advanced Science. 10.1002/advs.202524303
