| Field | Specification |
|---|---|
| Target | |
| Alternative names | Macrophage scavenger receptor types I and II; Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; CD antigen CD204; MSR1; SCARA1 |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human MSR1 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 17M78 is a rabbit monoclonal antibody that recognizes macrophage scavenger receptor types I and II (gene MSR1) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 49.8 kDa, and the supplier reports an observed band at about 75 kDa.
Macrophage scavenger receptor 1 (MSR1, SR-A, CD204) is a class A scavenger receptor on macrophages. It binds and takes up modified low-density lipoproteins such as oxidized and acetylated LDL, as well as bacterial components and apoptotic cell debris, so it is studied in foam cell formation during atherosclerosis and in innate immunity.
| Target | Macrophage scavenger receptor types I and II (gene MSR1; UniProt P21757, human) |
|---|---|
| Clone | 17M78 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 49.8 kDa |
| Observed MW | 75 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Samples with a confirmed band (WB): HeLa cells, mouse placenta.
Recommended loading (WB): 20–40 µg of total protein per lane.
Immunogen
Synthetic peptide based on the sequence of human MSR1.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places macrophage scavenger receptor types I and II in the cell membrane. Tissue expression noted by UniProt (human): Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Lifeng Yang et al. (2017) Macrophage differentiation induced by PMA is mediated by activation of RhoA/ROCK signaling. Journal of Toxicological Sciences. 10.2131/jts.42.763
