| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Cysteine protease ATG4C;3.4.22.-;AUT-like 3 cysteine endopeptidase;Autophagin-3;Autophagy-related cysteine endopeptidase 3;Autophagy-related protein 4 homolog C;ATG4C;APG4C, AUTL1, AUTL3; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human NDRG3 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-NDRG3 Rabbit Monoclonal Antibody catalog # M10017. Tested in WB, IHC applications. This antibody reacts with Human.
Protein: T-cell surface glycoprotein CD3 zeta chain | Gene: Cysteine protease ATG4C | Target: NDRG3 | Function: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. . | Research areas: Metabolism Processes,Oncoproteins,Oncoproteins/Suppressors,Pathways and Processes,Proteolysis/Ubiquitin,Proteolytic Enzymes,Signal Transduction
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 27N52 | Isotype: IgG | Reactivity: Human | Immunogen: A synthesized peptide derived from human NDRG3 | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB, IHC
Observed MW: 45 kDa | Calculated MW: 52497 MW
Cellular localization: Cytoplasm .
Tissue details: Highly expressed in skeletal muscle, heart, liver and testis. .
Status: Active
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