| Field | Specification |
|---|---|
| Target | |
| Alternative names | Glutamate receptor ionotropic, NMDA 2A; GluN2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A; GRIN2A |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human NMDAR2A |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 17G53 is a rabbit monoclonal antibody that recognizes glutamate receptor ionotropic, NMDA 2A (gene GRIN2A) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 165.3 kDa, and the supplier reports an observed band at about 165 kDa.
GluN2A (GRIN2A) is a glutamate-binding subunit of NMDA receptors that becomes dominant at many synapses after early development. It shapes the fast kinetics of NMDA currents and contributes to long-term potentiation, and GRIN2A variants are associated with epilepsy and speech disorders.
| Target | Glutamate receptor ionotropic, NMDA 2A (gene GRIN2A; UniProt Q12879, human) |
|---|---|
| Clone | 17G53 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 165.3 kDa |
| Observed MW | 165 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Immunogen
Synthetic peptide based on the sequence of human NMDAR2A.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places glutamate receptor ionotropic, NMDA 2A in the cell projection, cell membrane, synapse and postsynaptic cell membrane.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Rengong Zhuo et al. (2025) PPARα deletion induces depressive-like behaviors by impairing neuronal synaptic plasticity and transmission. Neuroscience. 10.1016/j.neuroscience.2025.07.029
